[태그:] addiction

  SHORT COMMUNICATION Significant association of DRD2 enhancer variant rs12364283 with heroin addiction in a Pakistani population Abstract The dopamine D2 receptor encoded by DRD2 has been implicated in multiple psychiatric disorders, mediated at least in part by two intronic variants affecting mRNA splicing, rs1076560 and rs2283265, and a less frequent enhancer variant, rs12364283, which increases DRD2 mRNA expression. This study tests whether these functionally validated variants confer susceptibility toward heroin ...